Drugging the undruggable with protein interference

Next generation functional screening enabled by high-fidelity Oligo Pools

Date & Time

September 30, 2020 | 8 am PDT (5 pm CEST)

Webinar Description

In the post-genome era, large-scale, gene-centric target discovery studies using tools such as RNAi and CRISPR have proliferated, and produced many insights into disease biology. Challenges remain however, as these tools often struggle to interrogate the subtle biological processes that govern clinical response.

Fortunately, new screening tools exist that can both find targets and uncover the mechanisms that modulate complex molecular interactions. One such tool is SITESEEKER®, developed by the scientists at PhoreMost.

In this webinar you will:
  • Hear how SITESEEKER® exploits protein interference (PROTEINi) to deliver a substantially greater magnitude of complexity than existing screening tools.
  • See how the path from target ID to drug development can be shortened using PROTEINi, through the discovery of druggable pockets in addition to targets.
  • Discover how this technology can be applied in key disease areas, including in cancer biology, neurodegeneration and for hijacking targeted protein degradation.
  • Learn why the length and fidelity of Twist Oligo Pools is enabling PhoreMost to develop the next generation of their platform.
Webinar Registration


Dr. Benedict Cross
CTO | PhoreMost

Ben joined PhoreMost in 2019 to direct the evolution and development of the SITESEEKER® screening platform. He is a geneticist and biotechnologist, with over ten years of professional research and management experience.

Before joining PhoreMost, Ben founded Horizon Discovery’s functional genomic screening platform. Using pooled and arrayed approaches and both RNAi and CRISPR, Ben led the platform’s growth from inception to an internationally acclaimed and multi-million-pound revenue-generating group, executing hundreds of screens per year.

Ben completed his PhD at the University of Manchester, with postdoctoral training at the University of Cambridge exploring the mechanisms of control in the unfolded protein response using reverse chemical genetic screening.
©. All Rights Reserved Twist Bioscience.