Chief Scientific Officer, Precision Health Research, Singapore (PRECISE)
Presentation Title: DNA methylation signatures for cardiovascular and metabolic disease
Professor John Chambers is Chief Scientific Officer (CSO) of PRECISE, the central entity established to implement Phase II of Singapore’s National Precision Medicine strategy. Prof Chambers is the lead investigator of the PRECISE-SG100K population cohort study, a multi-institutional effort that aims to study the genetic makeup of 100,000 healthy Singaporeans and specific disease cohorts. The genetic data will be integrated with detailed lifestyle, environmental, and clinical data to yield rich insights into factors that contribute to Asian diseases and conditions.
Prof Chambers’ own research focuses on identification of mechanisms underlying the high rate of cardiovascular disease and diabetes in Asian populations and translational research to improve prevention and control of these major diseases. He has been closely involved in large-scale prospective population studies in Europe, South Asia and Singapore. His research has contributed to the discovery of novel genetic and epigenetic pathways associated with coronary heart disease, type-2 diabetes, obesity, and related metabolic disturbances implicating new molecular pathways underlying these diseases.
As Professor of Cardiovascular Epidemiology at LKCMedicine, Prof Chambers will continue to focus on identifying new strategies for prediction and prevention of cardiovascular disease and diabetes. He also aims to aspire a new generation of researchers who will continue his efforts in identifying novel ways to predict and prevent cardiovascular diseases and diabetes. He hopes to achieve these through the research networks he has established in the region, the research platform at LKCMedicine and partner healthcare organisations.